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Dosing efficacy as well as circulating levels of GSH-T, the ratio of reduced to oxidized glutathione (GSH-F:GSSG) and concentrations of malondialdehyde (MDA), a lipid peroxide marker of oxidative stress, as well as that of total cysteine, an indicator of oxidation of reduced cysteine to oxidized forms of cysteine, were assessed as secondary efficacy outcomes

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Research efforts are urgently needed to elucidate the complex mechanisms underlying fluconazole resistance, particularly in emerging Candida species, to inform targeted therapeutic interventions and mitigate the growing impact of antifungal resistance in clinical settings [6]

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